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KMID : 0043319940170050378
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Archives of Pharmacal Research
1994 Volume.17 No. 5 p.378 ~ p.380
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Hydrolysis kinetics of Metampicillin by High Performance Liquid Chromatography
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Lee Hee-Yong
Jang Won-Cheoul
Lee Hye-Suk
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Abstract
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The hydrolysis of metampicillin to ampicillin was investigated using high perofrmance liquid chromatography. We developed the simultaneous determination of metampicillin and ampicilin using a Zorbox CN column and 5% acetonitrile and 8% methanol in 0.02 M phosphate buffer (pH 7.0) as mobile phase. Matampicillin was hdyrolyzed to ampicillin with half life of 41.5 min at physiological pH and temperature. In acdic pH, metampicillin was rapidly hydrolyzed to ampicillin within a chromatogrphic separation.
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KEYWORD
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Metampicillin, Ampicillin, High performance liquid chromatography, Kinetics of hydrolysis
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